α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体激活；不是方块舞。

AMPA receptor activation; not a square dance.

作者信息

Stern-Bach Yael

机构信息

The Institute of Basic Dental Science, The Hebrew University-Hadassah School of Dental Medicine, Jerusalem 91120, Israel.

出版信息

Neuron. 2004 Feb 5;41(3):309-11. doi: 10.1016/s0896-6273(04)00040-6.

DOI:10.1016/s0896-6273(04)00040-6

PMID:14766169

Abstract

AMPA receptors are tetramers assembled as a dimer-of-dimers with a 2-fold rotational symmetry in their extracellular domains. Two papers in this issue of Neuron, by Horning and Mayer and Sobolevsky et al., provide complementary data that extend this view and highlight the role of dimers in channel gating.

摘要

AMPA受体是四聚体，以二聚体的二聚体形式组装，在其细胞外结构域具有2倍旋转对称性。本期《神经元》杂志上霍宁与梅耶以及索博列夫斯基等人发表的两篇论文提供了补充数据，扩展了这一观点，并突出了二聚体在通道门控中的作用。