Xian Cory J, Zhou Xin-Fu
Department of Orthopaedic Surgery, Women's and Children's Hospital, Adelaide, Australia.
Front Biosci. 2004 Jan 1;9:85-92. doi: 10.2741/1210.
Evidence has suggested that the epidermal growth factor receptor (EGF-R) and its ligands are important regulators for development and maintenance of various tissues including the nerve system. Gene knockout, transgenic or other in vivo and in vitro studies have demonstrated that these molecules, produced by neurons and glial cells, play important roles in regulating neural/glial precursor cell or stem cell proliferation, migration, differentiation and survival, in maintaining tissue homeostasis, and in regulating CNS gliosis and peripheral nerve injury responses. These studies have revealed that, despite a possible functional redundancy among the individual EGF family ligands, collectively EGF-R ligands are required for development and maintenance of the nerve system.
有证据表明，表皮生长因子受体（EGF-R）及其配体是包括神经系统在内的各种组织发育和维持的重要调节因子。基因敲除、转基因或其他体内和体外研究表明，这些由神经元和神经胶质细胞产生的分子，在调节神经/胶质前体细胞或干细胞的增殖、迁移、分化和存活、维持组织稳态以及调节中枢神经系统胶质增生和外周神经损伤反应中发挥着重要作用。这些研究表明，尽管单个EGF家族配体之间可能存在功能冗余，但EGF-R配体共同对神经系统的发育和维持是必需的。
