Kolakowski L F, Leunissen J A, Smith J E
Renal Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129.
Biotechniques. 1992 Dec;13(6):919-21.
This report describes the implementation of ProSearch, a computer program that can efficiently search for motifs in protein sequences. ProSearch currently uses motifs that are contained in the PROSITE database, but user-developed patterns can easily be added to any search. ProSearch can generate a report identifying the patterns present in a given protein sequence, their locations and, if desired, a short description of the identified patterns. The program is written in AWK (a small interpreted computer language), which can run on all computer platforms commonly found in laboratories. ProSearch can search a 348-amino acid protein for 690 patterns in less than 5 s on a typical workstation.
本报告描述了ProSearch的实现情况，ProSearch是一个能够在蛋白质序列中高效搜索基序的计算机程序。ProSearch目前使用PROSITE数据库中包含的基序，但用户开发的模式可以轻松添加到任何搜索中。ProSearch可以生成一份报告，识别给定蛋白质序列中存在的模式、它们的位置，并在需要时对识别出的模式进行简短描述。该程序用AWK（一种小型解释型计算机语言）编写，可以在实验室中常见的所有计算机平台上运行。在典型的工作站上，ProSearch可以在不到5秒的时间内搜索一个348个氨基酸的蛋白质中的690种模式。
