Grekova N M, Lebedeva Iu V, Bordunovskiĭ V N
Vestn Khir Im I I Grek. 2003;162(5):78-81.
Under study was the influence of antimetabolite 5-fluoracil with the preferential influence on the lymphocytic link upon the outcomes of local operations in patients with diabetic foot syndrome. The investigation was performed in 95 diabetes mellitus patients who had undergone local operations for pyo-necrotic diseases of the foot. The group of investigation included 55 patients additionally given 5-fluoracil (5 mg/kg) during local operation. The injection of the drug was followed by moderate lympho- and thrombopenia arrested by the 7th day after a single injection, reduced content of the acute phase reactants and a dramatic drop of the content of circulating immune complexes. Clinically it was followed by a rapid disappearance of the inflammation signs in the wound. In the group of patients given 5-fluoracil there were reliably less reamputations, greater number of wounds healing by primary intention after the first local operation and of those successfully closed with the help of plastic operations. No general toxic effects of the used doses of the drug were noted.
研究了对淋巴细胞环节有优先影响的抗代谢物5-氟尿嘧啶对糖尿病足综合征患者局部手术结果的影响。对95例因足部脓性坏死性疾病接受局部手术的糖尿病患者进行了调查。研究组包括55例在局部手术期间额外给予5-氟尿嘧啶（5mg/kg）的患者。单次注射药物后，出现中度淋巴细胞减少和血小板减少，至第7天停止，急性期反应物含量降低，循环免疫复合物含量急剧下降。临床上，伤口炎症迹象迅速消失。在给予5-氟尿嘧啶的患者组中，再次截肢的情况确实较少，首次局部手术后一期愈合的伤口数量更多，借助整形手术成功闭合的伤口数量也更多。未观察到所用剂量药物的一般毒性作用。
