Oancea A, Popa E, Zărnescu O, Angelescu N
Facultatea de Biologie, Universitatea Bucureşti.
Chirurgia (Bucur). 2000 May-Jun;95(3):245-52.
Cicatrisant collagen compress are biomaterials performed from type I collagen purified. Experimental studies including trials carried out in vitro and in vivo, demonstrated the biocompatibility of these biomaterials and their effect on accelerating the process of dermic wound re-epithelization. A subsequent stage of our investigations consisted in clinical trial of these cicatrisant compresses. These were applied to post-traumatismal wounds of variable areas or to 2nd and 3rd degree of deeper burns. The obtained results demonstrated that collagen biomaterials as cicatrizing compresses are well tolerated by human organism, they do not cause inflammations, necroses or other undesirable phenomena at the site of application. Also it was found that these biomaterials are not antigenic, since anticollagen type I antibodies were not present in nome of the treated patients' serum and accelerate the epitelization.
促愈合胶原敷料是由纯化的I型胶原制成的生物材料。包括体外和体内试验在内的实验研究表明了这些生物材料的生物相容性及其对加速皮肤伤口再上皮化过程的作用。我们研究的后续阶段是对这些促愈合敷料进行临床试验。这些敷料应用于不同面积的创伤后伤口或二度和三度深度烧伤。获得的结果表明，作为促愈合敷料的胶原生物材料能被人体很好地耐受，在应用部位不会引起炎症、坏死或其他不良现象。还发现这些生物材料没有抗原性，因为在所有接受治疗患者的血清中都不存在抗I型胶原抗体，并且能加速上皮化。
