Uno Yoshihumi
Kansenshogaku Zasshi. 2003 Dec;77(12):1024-31. doi: 10.11150/kansenshogakuzasshi1970.77.1024.
To clarify the bacteriological interpretation of nasopharyngeal flora from infants and children with influenza (n = 38), nasopharyngeal swabs were obtained. From 38 patients, 83 strains of bacterias were obtained. Chief pathogenic bacteria isolated from infants and children with influenza were B. catarrhalis (28 strains), S. pneumoniae (22 strains), H. influenzae (19 strains), S. aureus (6 strains) and chief nonpathogenic bacteria isolated from infants and children with influenza were Corynebacterium spp. and alpha-streptococcus (3 strains each) and Moraxella sp (2 strains). From infants and children without influenza (n = 34), 83 strains were obtained. The chief pathogenic bacteria isolated from infants and children without influenza were B. catarrhalis (23 strains), H. influenzae (22 strains), S. pneumoniae (18 strains), S. aureus (7 strains) and chief nonpathogenic bacteria isolated from infants and children without influenza were Corynebacterium spp. and Moraxella sp (5 strains each), alpha-streptococcus (2 strains) and Neisseria sp (1 strain). There was no significant difference in nasopharyngeal flora between infants and children with influenza and infants and children without influenza. In cases showing detection of multiple bacterial strains, common combinations were one or more of B. catarrhalis, S. pneumoniae, H. influenzae, S. aureus and nonpathogenic or weakly pathogenic bacteria. There was also no significant difference in combinations of nasopharyngeal flora between infants and children with influenza and those without influenza. We emphasize that we must study whether a difference in nasopharyngeal flora between infants and children with influenza and infants and children without influenza develops with time. Therefore, we must repeatedly obtain nasopharyngeal swabs from infants and children with influenza and infants and children without influenza.
为明确流感患儿（n = 38）鼻咽部菌群的细菌学解释，采集了鼻咽拭子。从38例患者中获得了83株细菌。从流感患儿中分离出的主要病原菌为卡他莫拉菌（28株）、肺炎链球菌（22株）、流感嗜血杆菌（19株）、金黄色葡萄球菌（6株），从流感患儿中分离出的主要非病原菌为棒状杆菌属和α-链球菌（各3株）以及莫拉克斯菌属（2株）。从无流感的婴幼儿（n = 34）中获得了83株细菌。从无流感的婴幼儿中分离出的主要病原菌为卡他莫拉菌（23株）、流感嗜血杆菌（22株）、肺炎链球菌（18株）、金黄色葡萄球菌（7株），从无流感的婴幼儿中分离出的主要非病原菌为棒状杆菌属和莫拉克斯菌属（各5株）、α-链球菌（2株）和奈瑟菌属（1株）。流感患儿与无流感的婴幼儿的鼻咽部菌群无显著差异。在检测到多种菌株的病例中，常见组合为卡他莫拉菌、肺炎链球菌、流感嗜血杆菌、金黄色葡萄球菌中的一种或多种以及非致病性或弱致病性细菌。流感患儿与无流感的婴幼儿的鼻咽部菌群组合也无显著差异。我们强调必须研究流感患儿与无流感的婴幼儿的鼻咽部菌群差异是否会随时间发展。因此，我们必须反复从流感患儿和无流感的婴幼儿中采集鼻咽拭子。
