O'Shaughnessy Joyce
Baylor-Charles A. Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas, USA.
Oncology (Williston Park). 2003 Dec;17(12 Suppl 14):15-21.
Gemcitabine has been evaluated in combination with paclitaxel, docetaxel, anthracyclines, vinorelbine, and cisplatin as first-line treatment and after prior chemotherapy in patients with metastatic breast cancer. Results with gemcitabine/taxane combinations have been especially encouraging, with these combinations providing promising outcomes with regard both to tumor response and tolerability. The combination of gemcitabine and paclitaxel has garnered particular interest for further phase III evaluation on the basis of high response rates and durable responses in both treatment-naive and treatment-experienced patients, including anthracycline-pretreated patients.
吉西他滨已被评估与紫杉醇、多西他赛、蒽环类药物、长春瑞滨和顺铂联合，用于转移性乳腺癌患者的一线治疗以及先前化疗之后的治疗。吉西他滨与紫杉烷联合用药的结果尤其令人鼓舞，这些联合用药在肿瘤反应和耐受性方面均带来了有前景的结果。基于在初治患者和经治患者（包括接受过蒽环类药物预处理的患者）中均有较高的缓解率和持久缓解，吉西他滨与紫杉醇的联合用药引起了特别关注，有待进一步进行III期评估。
