使用带有单分散聚甲基丙烯酸缩水甘油酯微球的官能团测定大鼠血液中的体外吞噬活性。
Measurement of in vitro phagocytic activity using functional groups carrying monodisperse poly(glycidyl methacrylate) microspheres in rat blood.
作者信息
Ulusoy Ayse, Onur Mehmet Ali
机构信息
Hacettepe University, Faculty of Science, Department of Biology, Ankara, Turkey.
出版信息
J Biomater Sci Polym Ed. 2003;14(11):1299-310. doi: 10.1163/156856203322553509.
Phagocytic activity of monocyte and neutrophil leukocytes in rat blood was investigated using monodisperse poly(glycidyl methacrylate) (poly(GMA)) microspheres. Interactions of monocyte and neutrophil leukocytes with plain poly(GMA), charged poly(GMA)-NH2 and biomodified poly(GMA) (poly(GMA)-albumin and opsonized poly(GMA)) was studied as a function of time. Here we report the cellular phagocytosis rate of particles and the total internalised particle amount. Phagocytes showed higher phagocytic activity for poly(GMA) microspheres carrying functional groups versus plain poly(GMA) particles. Phagocytic activity was the highest for opsonized poly(GMA) microspheres (P < 0.05).
使用单分散聚甲基丙烯酸缩水甘油酯（聚（GMA））微球研究了大鼠血液中单核细胞和中性粒细胞的吞噬活性。研究了单核细胞和中性粒细胞与普通聚（GMA）、带电聚（GMA）-NH2以及生物改性聚（GMA）（聚（GMA）-白蛋白和调理素化聚（GMA））之间的相互作用随时间的变化。在此，我们报告了颗粒的细胞吞噬率和内化颗粒总量。与普通聚（GMA）颗粒相比，吞噬细胞对带有官能团的聚（GMA）微球表现出更高的吞噬活性。调理素化聚（GMA）微球的吞噬活性最高（P < 0.05）。
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