Nafee Noha Adel, Boraie Mabila Ahmed, Ismail Fatma Ahmed, Mortada Lobna Mohamed
Department of Pharmaceutics, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt.
Acta Pharm. 2003 Sep;53(3):199-212.
Mucoadhesive patches for delivery of cetylpyridinium chloride (CPC) were prepared using polyvinyl alcohol (PVA), hydroxyethyl cellulose (HEC) and chitosan. Swelling and bioadhesive characteristics were determined for both plain and medicated patches. The results showed a remarkable increase in radial swelling (S(D)) after addition of the water-soluble drug (CPC) to the plain formulae. A decrease in the residence time was observed for PVA and chitosan-containing formulae. Higher drug release was obtained from PVA patches compared to HEC ones, while both are non-ionic polymers. A considerable drop in release was observed for chitosan formulae after the addition of water-soluble additives, polyvinyl pyrrolidone (PVP) and gelatin. Ageing was done on PVA formulae; the results showed there was no influence on the chemical stability of CPC, as reflected from the drug content data. Physical characteristics of the studied patches showed an increase in the residence time with storage accompanied with a decrease in drug release. This may be due to changes in the crystal habit of the drug as well as to slight agglomeration of the polymer particles.
使用聚乙烯醇（PVA）、羟乙基纤维素（HEC）和壳聚糖制备了用于递送西吡氯铵（CPC）的黏膜黏附贴片。测定了空白贴片和含药贴片的溶胀特性和生物黏附特性。结果表明，在空白配方中加入水溶性药物（CPC）后，径向溶胀（S(D)）显著增加。含PVA和壳聚糖的配方的停留时间有所减少。与HEC贴片相比，PVA贴片的药物释放更高，而两者均为非离子聚合物。在加入水溶性添加剂聚乙烯吡咯烷酮（PVP）和明胶后，壳聚糖配方的释放量显著下降。对PVA配方进行了老化处理；结果表明，从药物含量数据反映出，这对CPC的化学稳定性没有影响。所研究贴片的物理特性表明，随着储存时间的延长，停留时间增加，同时药物释放减少。这可能是由于药物晶型的变化以及聚合物颗粒的轻微团聚所致。
