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某些[2-氨基-6-(4-取代芳基)-4-(4-取代苯基)-1,6-二氢嘧啶-5-基]-乙酸衍生物的合成及抗炎活性

Synthesis and anti-inflammatory activity of some [2-amino-6-(4-substituted aryl)-4-(4-substituted phenyl)-1,6-dihydropyrimidine-5-yl]-acetic acid derivatives.

作者信息

Bahekar Sushilkumar S, Shinde Devanand B

机构信息

Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431 004 MS, India.

出版信息

Acta Pharm. 2003 Sep;53(3):223-9.

PMID:14769245
Abstract

Dihydropyrimidines 4a-r have been synthesized by base catalysed condensation of beta-aroylpropanoic acid, guanidine nitrate and aromatic aldehyde. Structures of the new compounds were established on the basis of 1H NMR and IR spectral data. Anti-inflammatory activity in vivo was evaluated and compared with standard drug diclofenac sodium.

摘要

通过β-芳酰基丙酸、硝酸胍和芳香醛的碱催化缩合反应合成了二氢嘧啶4a-r。根据1H NMR和IR光谱数据确定了新化合物的结构。评估了其体内抗炎活性，并与标准药物双氯芬酸钠进行了比较。

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