Dimitrov Milen, Lambov Nikoali, Shenkov Stoicho, Dosseva Veneta, Baranovski Valdimir Y
Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Sofia, Bulgaria.
Acta Pharm. 2003 Mar;53(1):25-31.
This study is an attempt of biopharmaceutical characterization of hydrogels based on crosslinked polyacrylic acid (PAA). Macrodiisocyanates (MDIC) or oligomethanediisocyanate (DO) were used as crosslinking agents. The drug release rate from such hydrogels is determined by the density of the net and is lowered by a decrease in the PAA : MDIC mass ratio. The increase of the drug concentration in the matrix improved the release process. The drug release from the hydrogels was found to be pH dependent.
本研究旨在对基于交联聚丙烯酸（PAA）的水凝胶进行生物药剂学表征。使用了大分子二异氰酸酯（MDIC）或低聚亚甲基二异氰酸酯（DO）作为交联剂。此类水凝胶的药物释放速率由网络密度决定，且随着PAA与MDIC质量比的降低而降低。基质中药物浓度的增加改善了释放过程。发现水凝胶的药物释放依赖于pH值。
