Zucker Irving H, Schultz Harold D, Li Yi-Fan, Wang Yu, Wang Wei, Patel Kaushik P
Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, NE 68198-4575, USA.
Prog Biophys Mol Biol. 2004 Feb-Apr;84(2-3):217-32. doi: 10.1016/j.pbiomolbio.2003.11.010.
The regulation of sympathetic nerve activity in chronic heart failure (CHF) has been an area of renewed investigation. Understanding the central mechanisms that are responsible for sympatho-excitation in this disease state may help in reducing the deleterious effects of chronic sympatho-excitation. This review will summarize our understanding of abnormal reflex control of the circulation in CHF. The roles of the arterial baroreflex, the chemoreflex, the cardiac sympathetic afferent reflex and the cardiopulmonary reflex are discussed. New experimental techniques that allow genetic manipulation of substances such as nitric oxide synthase in discrete areas of the brain aid in clarifying the role of NO in the modulation of sympathetic tone in the CHF state. Lastly, clinical implications of this work are discussed.
慢性心力衰竭（CHF）中交感神经活动的调节一直是重新研究的领域。了解导致这种疾病状态下交感神经兴奋的中枢机制可能有助于减轻慢性交感神经兴奋的有害影响。本综述将总结我们对CHF中循环异常反射控制的理解。讨论了动脉压力反射、化学反射、心脏交感传入反射和心肺反射的作用。新的实验技术允许在大脑离散区域对一氧化氮合酶等物质进行基因操作，有助于阐明一氧化氮在CHF状态下调节交感神经张力中的作用。最后，讨论了这项工作的临床意义。
