Lucarelli Maria R, Shirk Mary Beth, Julian Mark W, Crouser Elliott D
Division of Pulmonary and Critical Care Medicine, Department of Pharmacy, The Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University Medical Center, 473 West Twelfth Avenue, Columbus, OH 43210-1252, USA.
Chest. 2004 Feb;125(2):793-5. doi: 10.1378/chest.125.2.793.
Food Drug and Cosmetic Blue No. 1 dye (FD&C Blue No. 1) is commonly added to enteral nutrition formulations in order to facilitate the detection of gastric aspirate in tracheal secretions of critically ill patients. However, reports of systemic blue dye absorption and associated adverse outcomes are emerging. We report two cases of abnormal systemic absorption of FD&C Blue No. 1 in critically ill patients who subsequently died of refractory shock and metabolic acidosis. Risk factors and mechanisms of FD&C Blue No. 1 toxicity are discussed, and alternate approaches to gastric aspiration detection in critically ill patients are considered.
食品药品及化妆品蓝色一号染料（FD&C 蓝色一号）通常被添加到肠内营养制剂中，以便于在重症患者的气管分泌物中检测胃吸出物。然而，关于系统性蓝色染料吸收及相关不良后果的报告不断出现。我们报告了两例重症患者出现 FD&C 蓝色一号系统性异常吸收的病例，这两名患者随后死于难治性休克和代谢性酸中毒。文中讨论了 FD&C 蓝色一号毒性的危险因素和机制，并考虑了重症患者胃吸出物检测的替代方法。
