Samuels Steven C, Brickman Adam M, Burd Jeremy A, Purohit Dushyant P, Qureshi Pervaiz Q, Serby Michael
Department of Psychiatry, Box 1230, Mount Sinai School of Medicine, One East 100th Street, New York, NY 10029, USA.
Mt Sinai J Med. 2004 Jan;71(1):55-62.
Depression has frequently been cited as a manifestation of dementia with Lewy bodies (DLB). Previous studies have suggested an increase of depression in patients with DLB, compared to those with Alzheimer's disease (AD). The purpose of this study was to examine depressive symptomatology in nursing home residents, from a consecutive series of DLB (n=16) and AD (n=39) autopsy-confirmed cases. Subjects received standard neuropathological analysis and postmortem chart review for clinical assessment of depression. Depressive symptomatology did not differ between the AD and DLB groups, and there was no significant relationship between depression and cortical or subcortical Lewy body (LB) count in the locus ceruleus or substantia nigra. This study suggests that the presence or absence of depression cannot be used to distinguish between AD and DLB. Furthermore, depressive symptomatology in DLB does not appear to be related to severity of cortical or subcortical LB pathology.
抑郁症常被认为是路易体痴呆（DLB）的一种表现形式。先前的研究表明，与阿尔茨海默病（AD）患者相比，DLB患者的抑郁症发病率有所增加。本研究的目的是从一系列经尸检确诊的DLB（n = 16）和AD（n = 39）病例中，检查养老院居民的抑郁症状。受试者接受了标准的神经病理学分析和死后病历审查，以进行抑郁症的临床评估。AD组和DLB组之间的抑郁症状没有差异，并且抑郁症与蓝斑或黑质中皮质或皮质下路易小体（LB）计数之间没有显著关系。这项研究表明，抑郁症的存在与否不能用于区分AD和DLB。此外，DLB中的抑郁症状似乎与皮质或皮质下LB病理的严重程度无关。
