Scott Mark G H, Benmerah Alexandre, Marullo Stefano
Institut Cochin, Départements de Biologie Cellulaire et de Maladies Infectieuses, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France.
Med Sci (Paris). 2004 Jan;20(1):78-83. doi: 10.1051/medsci/200420178.
Most G protein-coupled receptors (GPCR) are rapidly internalized upon agonist stimulation. From the large number of studies available to date on receptor endocytosis, substantial differences seem to exist among GPCRs in terms of both the molecular pathways of receptor internalization and the biological significance of this process. The aim of this review is to outline common themes in GPCR endocytosis and to delineate true phenotypic variations, which reflect specific necessities for receptor's function.
大多数G蛋白偶联受体（GPCR）在激动剂刺激后会迅速内化。从迄今为止有关受体内吞作用的大量研究来看，GPCRs在受体内化的分子途径和这一过程的生物学意义方面似乎存在很大差异。本综述的目的是概述GPCR内吞作用的共同主题，并描述真正的表型变异，这些变异反映了受体功能的特定需求。
