Cooperstock M, DuPont H L, Corrado M L, Fekety R, Murray D M
Department of Pediatrics, University of Missouri Medical School, Columbia.
Clin Infect Dis. 1992 Nov;15 Suppl 1:S254-8. doi: 10.1093/clind/15.supplement_1.s254.
Entamoeba histolytica causes colonic infection that ranges from asymptomatic carriage to invasive disease with infection of extraintestinal organs, particularly the liver. The disease occurs in both sporadic and epidemic forms. Diagnosis requires visualization of trophozoites or cysts by microscopic examination of stool, colonic scrapings, or biopsy specimens. Patients with either asymptomatic or symptomatic disease may be eligible for clinical trials. A prospective, randomized, double-blind, placebo-controlled study design is recommended for asymptomatic carriers and an active-concurrent-control study design for symptomatic patients. Final outcome should be assessed 48 hours to 7 days after completion of therapy. Assessment of microbiological outcome is paramount.
溶组织内阿米巴可引起结肠感染，其感染程度从无症状携带到伴有肠外器官（尤其是肝脏）感染的侵袭性疾病不等。该疾病以散发和流行两种形式出现。诊断需要通过对粪便、结肠刮片或活检标本进行显微镜检查来观察滋养体或包囊。无症状或有症状疾病的患者都可能符合临床试验条件。对于无症状携带者，建议采用前瞻性、随机、双盲、安慰剂对照的研究设计；对于有症状的患者，则采用活性同期对照研究设计。治疗结束后48小时至7天应评估最终结果。微生物学结果的评估至关重要。
