Al'perovich D V, Kesel'man E V, Shepelev A P, Chernavskaia L N
Biull Eksp Biol Med. 1992 Sep;114(9):272-4.
The interaction between milk xanthine oxidase (XO) and lactoperoxidase (LP) in model system and antimicrobial action of these enzymes on Escherichia coli 0-111 were studied. It was shown, that bacterial superoxide dismutase (SOD), which transforms O2-. (XO-reaction product) into H2O2 (substrate of LP), is necessary for binding of the reaction sequence: XO-->LP-->antimicrobial products. It is suggested, that these enzymes unite in the protective system in intestinal infections of newborns. Bacterial SOD in this case acts as the key factor, creating the system.
研究了模型系统中牛奶黄嘌呤氧化酶（XO）与乳过氧化物酶（LP）之间的相互作用，以及这些酶对大肠杆菌O-111的抗菌作用。结果表明，将O2-（XO反应产物）转化为H2O2（LP的底物）的细菌超氧化物歧化酶（SOD）对于反应序列XO→LP→抗菌产物的结合是必需的。有人提出，这些酶在新生儿肠道感染的保护系统中结合在一起。在这种情况下，细菌SOD作为创建该系统的关键因素发挥作用。
