Steinsapir J
Department of Physiology and Endocrinology, Medical College of Georgia, Augusta 30912-3000.
Receptor. 1992 Spring;2(1):45-76.
Target tissues contain microsomal receptors for steroid hormones. High-affinity, low-capacity binding sites for steroids are located in the endoplasmic reticulum and do not bind DNA. Studies by diverse groups on the nature and function of these receptors using biochemical and morphological approaches are discussed. The findings indicate that microsomes can be the site of receptor synthesis. Microsomes can also play a role in the control of receptor recycling and/or receptor processing after the complexes exit the nucleus of target cells. Moreover, microsomal receptors may be involved in posttranscriptional actions of steroid hormones.
靶组织含有类固醇激素的微粒体受体。类固醇的高亲和力、低容量结合位点位于内质网，且不与DNA结合。本文讨论了不同研究小组使用生化和形态学方法对这些受体的性质和功能进行的研究。研究结果表明，微粒体可能是受体合成的场所。在复合物离开靶细胞的细胞核后，微粒体在受体循环利用和/或受体加工的控制中也可能发挥作用。此外，微粒体受体可能参与类固醇激素的转录后作用。
