YUILE C L, HAYDEN J W, BUSH J A, TESLUK H, STEWART W B
J Exp Med. 1950 Oct 1;92(4):367-73. doi: 10.1084/jem.92.4.367.
The absorption of a test amount of radioactive iron during artificial saturation of the plasma iron-binding protein, by the repeated intravenous injection of small amounts of iron, was measured in three normal and four anemic dogs. The procedure had no detectable influence on the iron absorption of the normal dogs nor on that of two of the anemic dogs. Two other anemic dogs showed some suppression of iron absorption, though the amount absorbed was still in excess of that absorbed by a normal dog. The reasons for this suppression are not clear from these experiments. Artificially raising the plasma iron to normal levels in one anemic dog did not influence the absorption of iron from the gastrointestinal tract nor was a delayed effect noted after the plasma iron had fallen to base line levels after 5 hours of artificial saturation. It appears that the plasma iron-binding protein and its relative saturation play little role per se in the control of iron absorption in dogs.
通过反复静脉注射少量铁使血浆铁结合蛋白人工饱和后，测定了3只正常犬和4只贫血犬对一定测试量放射性铁的吸收情况。该操作对正常犬的铁吸收以及其中2只贫血犬的铁吸收均未产生可检测到的影响。另外2只贫血犬的铁吸收出现了一定程度的抑制，不过吸收量仍超过正常犬的吸收量。从这些实验中尚不清楚这种抑制的原因。在1只贫血犬中人工将血浆铁提高到正常水平，既未影响胃肠道对铁的吸收，在人工饱和5小时后血浆铁降至基线水平后也未观察到延迟效应。看来血浆铁结合蛋白及其相对饱和度本身在犬铁吸收的控制中作用不大。
