Yuan M
Cancer Research Laboratory, General Hospital of PLA, Beijing.
Zhonghua Bing Li Xue Za Zhi. 1992 Jun;21(3):139-41.
Human mucin core cDNA-MUC-2 has been cloned and sequenced. Its major portion consists of amino acids tandem in arrangement with repetition in its sequence, locating at the 11th chromosome. Antibody against polypeptide MUC-2 was used for immunohistochemical SABC staining in order to investigate the expression of MUC-2 in human normal and cancerous tissues. The results revealed that MUC-2 was expressed in normal intestine and prostate, and accumulated in the colorectal cancer tissues, but not in other normal tissues or only weakly expressed in a few cases of pancreas, lung and breast cancers. If used in combining with monoclonal antibody against MUC-1, which is known to be expressed in normal and cancer tissues of pancreas, lung and breast, it is considered to be valuable for the differential diagnosis in detecting the origin of metastatic adenocarcinoma.
人黏蛋白核心cDNA-MUC-2已被克隆和测序。其主要部分由氨基酸串联排列且序列重复组成，位于第11号染色体上。采用抗多肽MUC-2抗体进行免疫组织化学SABC染色，以研究MUC-2在人正常组织和癌组织中的表达。结果显示，MUC-2在正常肠和前列腺中表达，并在结直肠癌组织中积聚，但在其他正常组织中不表达或仅在少数胰腺癌、肺癌和乳腺癌病例中弱表达。如果与已知在胰腺、肺和乳腺的正常组织和癌组织中表达的抗MUC-1单克隆抗体联合使用，它被认为对检测转移性腺癌的起源进行鉴别诊断有价值。
