Currie M S
Duke University Medical Center.
Compr Ther. 1992 Nov;18(11):26-34.
The aging immune system, while showing little in the way of quantitative changes, demonstrates important functional changes, especially T-cell functions. In addition to increased susceptibility to some infections, there is an increased likelihood of autoantibody production, and the emergence of monoclonal antibodies and other lymphoproliferative disorders. The role of the immune system in degenerative processes, and susceptibility to malignant processes requires further investigation. Biotechnology is producing many new methods of modulating immune function, with ever increasing specificity. Thus the future holds great promise for overcoming the effects of immunosenescence.
衰老的免疫系统虽然在数量变化方面表现不明显，但却呈现出重要的功能变化，尤其是T细胞功能。除了对某些感染的易感性增加外，自身抗体产生的可能性也增加，并且会出现单克隆抗体和其他淋巴增生性疾病。免疫系统在退行性过程中的作用以及对恶性过程的易感性需要进一步研究。生物技术正在产生许多调节免疫功能的新方法，其特异性也在不断提高。因此，未来在克服免疫衰老的影响方面有着巨大的前景。
