Weatherall D, Sarvetnick N, Shizuru J A
Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford, UK.
Diabetologia. 1992 Dec;35 Suppl 2:S1-7. doi: 10.1007/BF00586273.
Genetic inheritance predisposing individuals to diabetes mellitus was discussed in this work group. The two forms of the disease, Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) were discussed separately since the pattern of inheritance and genes involved appear to be distinctly different. Within these subtypes there is considerable genetic heterogeneity, and superimposed environmental factors confound the analysis. New technologies that will allow finer molecular analysis, as well as new candidates genes, were presented.
该工作小组讨论了使个体易患糖尿病的遗传因素。由于1型（胰岛素依赖型）和2型（非胰岛素依赖型）这两种糖尿病的遗传模式和相关基因明显不同，因此分别进行了讨论。在这些亚型中存在相当大的遗传异质性，并且叠加的环境因素使分析变得复杂。会上介绍了能够进行更精细分子分析的新技术以及新的候选基因。
