Staner L, De La Fuente J M, Kerkhofs M, Linkowski P, Mendlewicz J
Department of Psychiatry, Erasme Hospital, Free University of Brussels, Belgium.
J Affect Disord. 1992 Dec;26(4):241-5. doi: 10.1016/0165-0327(92)90101-b.
Recurrent brief depression (RBD) has recently been proposed as a new subtype of affective disorder characterized by episodes of major depression which last less than two weeks. The aim of this study was to further evaluate the validity of this putative subtype by means of clinical and biological data. DST, TSH response to TRH and sleep EEG variables were compared in 25 RBD patients sex- and age-matched to 25 major depressed (MD) and 25 healthy subjects. Family history, age at onset, and psychiatric comorbidity did not discriminate RBD from MD. Recurrent unipolar depression was found to be more prevalent in MD. Although less severely depressed during the biological tests, patients with RBD did not significantly differ from those with MDD on basis of DST non-suppression, blunted TSH response and shortening of REM latency. Compared to controls, a greater sleep onset latency was observed both in RBD and MD and a lower total sleep time in MD patients only. These results suggest that RBD could be viewed as a subtype of affective disorder sharing many characteristics with MDD.
复发性短暂抑郁症（RBD）最近被提出作为情感障碍的一种新亚型，其特征为重度抑郁发作持续时间少于两周。本研究的目的是通过临床和生物学数据进一步评估这一假定亚型的有效性。对25例RBD患者、25例重度抑郁（MD）患者以及25例健康受试者进行了地塞米松抑制试验（DST）、促甲状腺激素（TSH）对促甲状腺激素释放激素（TRH）的反应以及睡眠脑电图变量的比较，这些患者在性别和年龄上相互匹配。家族史、发病年龄和精神科共病情况并不能区分RBD和MD。发现复发性单相抑郁在MD中更为常见。尽管在生物学测试期间RBD患者的抑郁程度较轻，但基于DST不抑制、TSH反应迟钝和快速眼动睡眠潜伏期缩短，RBD患者与重度抑郁症（MDD）患者并无显著差异。与对照组相比，RBD患者和MD患者均观察到更长的入睡潜伏期，仅MD患者的总睡眠时间较短。这些结果表明，RBD可被视为情感障碍的一种亚型，与MDD具有许多共同特征。
