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苏丹萨哈法镇风湿热和风湿性心脏病的流行病学调查。

An epidemiological survey of rheumatic fever and rheumatic heart disease in Sahafa Town, Sudan.

作者信息

Ibrahim-Khalil S, Elhag M, Ali E, Mahgoub F, Hakiem S, Omer N, Shafie S, Mahgoub E

机构信息

Shaab Teaching Hospital, Khartoum, Sudan.

出版信息

J Epidemiol Community Health. 1992 Oct;46(5):477-9. doi: 10.1136/jech.46.5.477.

Abstract

STUDY OBJECTIVE

The aim was to determine the prevalence of rheumatic fever and rheumatic heart disease and to initiate a programme of secondary prophylaxis in Sahafa Town, Sudan.

DESIGN

The study was a prospective case finding survey, carried out by a specially trained team headed by a cardiologist.

SETTING

The study involved high risk school children (5-15 years of age) from Sahafa Town in the period 1986-1989.

SUBJECTS

A total of 13,332 children on the school registers (7892 boys and 5430 girls) were examined generally and specifically for evidence of rheumatic fever or rheumatic heart disease.

MAIN RESULTS

Out of the 13,322 children screened 351 were suspected cases and 146 were confirmed cases of rheumatic fever or rheumatic heart disease. The prevalence rates for all ages were 10/1000 for boys and 14/1000 for girls. The overall prevalence rate of the whole programme area was 11/1000, prevalence of rheumatic fever was 8/1000, and prevalence of rheumatic heart disease was 3/1000. The prevalence rate was significantly increased among the inner town inhabitants (15/1000) compared to the outer town inhabitants 4/1000 (p < 0.001). Monthly prophylactic benzathine penicillin in a dose of 1,200,000 IU was given to both suspected and confirmed cases. Penicillin coverage rate was 72%.

CONCLUSIONS

Rheumatic fever continues to be a serious health problem. With economic pressures causing impending change in socioeconomic conditions in most Third World countries in the immediate future, rheumatic fever will continue to have a high prevalence rate and rheumatic fever and rheumatic heart disease prevention programmes will remain a central goal.

摘要

研究目的

旨在确定苏丹萨哈法镇风湿热和风湿性心脏病的患病率,并启动二级预防计划。

设计

该研究是一项前瞻性病例发现调查,由一名心脏病专家领导的经过专门培训的团队进行。

背景

该研究涉及1986年至1989年期间萨哈法镇的高危学龄儿童(5至15岁)。

研究对象

对学校登记册上的13332名儿童(7892名男孩和5430名女孩)进行了全面检查,并特别检查了风湿热或风湿性心脏病的证据。

主要结果

在筛查的13322名儿童中,351例为疑似病例,146例为风湿热或风湿性心脏病确诊病例。各年龄段男孩的患病率为10/1000,女孩为14/1000。整个项目区域的总体患病率为11/1000,风湿热患病率为8/1000,风湿性心脏病患病率为3/1000。与城外居民的4/1000相比,城内居民的患病率显著增加(15/1000,p<0.001)。对疑似病例和确诊病例均给予每月120万国际单位剂量的苄星青霉素进行预防。青霉素覆盖率为72%。

结论

风湿热仍然是一个严重的健康问题。由于经济压力在不久的将来会导致大多数第三世界国家的社会经济状况发生迫在眉睫的变化,风湿热将继续保持高患病率,风湿热和风湿性心脏病预防计划仍将是一个核心目标。

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