Keller R K, Standert M
Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine.
J Fla Med Assoc. 1992 Nov;79(11):775-7.
GTPases represent a large family of proteins involved in a wide variety of cellular processes. They function as switches in which they are "on" in the GTP bound state and "off" in the GDP bound state. The "on" and "off" states are regulated by proteins which interact with the GTPases and enhance their rate of either GTP hydrolysis or GDP-GTP exchange. Thus far, GTPases have been shown to be involved in protein synthesis, signal transduction, control of cell growth, and intracellular transport.
GTP酶是一大类参与多种细胞过程的蛋白质。它们起着开关的作用，在结合GTP的状态下处于“开启”状态，而在结合GDP的状态下处于“关闭”状态。“开启”和“关闭”状态由与GTP酶相互作用并提高其GTP水解或GDP-GTP交换速率的蛋白质调节。到目前为止，GTP酶已被证明参与蛋白质合成、信号转导、细胞生长控制和细胞内运输。
