血卟啉衍生物：在生物体内的分布

Haematoporphyrin derivatives: distribution in a living organism.

作者信息

Mironov A F, Seylanov A S, Seylanov J A, Pizhik V M, Deruzhenko I V, Nockel A J

机构信息

M.V. Lomonosov Institute of Fine Chemical Technology, Moscow, Russian Federation.

出版信息

J Photochem Photobiol B. 1992 Dec;16(3-4):341-6. doi: 10.1016/1011-1344(92)80021-m.

DOI:10.1016/1011-1344(92)80021-m

PMID:1479475

Abstract

Pharmacokinetics of accumulation in organs and tissues was studied for two haematoporphyrin-based photosensitizers. These sensitizers, haematoporphyrin derivative (HpD) and an oligomeric haematoporphyrin (OHp), contained different amounts of monomeric fraction (25% and 5% respectively) and in OHp the macrocycles were bonded together with ether bonds. OHp was shown to accumulate in tumours in higher amounts than HpD. The maximal tumour to tissue concentration ratio for OHp was 6.7 observed 54 h after injection; the same ratio for HpD was 2.8 after 48 h.

摘要

研究了两种基于血卟啉的光敏剂在器官和组织中的蓄积药代动力学。这些光敏剂，即血卟啉衍生物（HpD）和一种低聚血卟啉（OHp），含有不同量的单体部分（分别为25%和5%），并且在OHp中，大环通过醚键连接在一起。结果表明，OHp在肿瘤中的蓄积量高于HpD。注射后54小时观察到OHp的最大肿瘤与组织浓度比为6.7；HpD在48小时后的相同比值为2.8。