对吗啡产生身体依赖性但未伴随耐受性形成。
Development of physical dependence on morphine not accompanied with tolerance formation.
作者信息
Ohta A, Kaneto H
机构信息
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University, Japan.
出版信息
J Pharmacobiodyn. 1992 Aug;15(8):443-7. doi: 10.1248/bpb1978.15.443.
The development of tolerance induced by daily repeated administration of 10 mg/kg of s.c. morphine was suppressed by combined injection of adrenergic blockers, 10 mg/kg i.p. phentolamine or propranolol, in mice. However, this treatment could not prevent the development of physical dependence as evidenced by the naloxone precipitated abstinence signs. Thus, we provide a new evidence that morphine analgesia, tolerance and physical dependence is dissociable from each other.
在小鼠中，每日皮下注射10毫克/千克吗啡诱导产生的耐受性发展，可被联合注射肾上腺素能阻滞剂（10毫克/千克腹腔注射酚妥拉明或普萘洛尔）所抑制。然而，这种处理并不能预防身体依赖性的发展，纳洛酮诱发的戒断症状就证明了这一点。因此，我们提供了新的证据，表明吗啡的镇痛、耐受性和身体依赖性是彼此可分离的。
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