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2-(aminoalkyl)-5-nitropyrazolo[3,4,5-kl]acridines, a new class of anticancer agents.

作者信息

Capps D B, Dunbar J, Kesten S R, Shillis J, Werbel L M, Plowman J, Ward D L

机构信息

Warner-Lambert/Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan 48106.

出版信息

J Med Chem. 1992 Dec 25;35(26):4770-8. doi: 10.1021/jm00104a001.

DOI:10.1021/jm00104a001
PMID:1479579
Abstract

2-(Aminoalkyl)-5-nitropyrazolo[3,4,5-kl]acridines were prepared from substituted anilines via the 1-chloro-4-nitroacridones followed by condensation with [(alkylamino)alkyl]hydrazines. Impressive activity was demonstrated for the 9-hydroxy, 9-alkoxy, and 9-acyloxy analogs in vitro on a L1210 leukemia line and in vivo against the P388 leukemia. Advanced studies led to the selection of 3bbb for clinical trial.

摘要

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