Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Asp-carboxylate of RGDX mimetics and the platelet GP IIb-IIIa receptor.
作者信息
Zablocki J A, Miyano M, Rao S N, Panzer-Knodle S, Nicholson N, Feigen L
机构信息
Department of Medicinal Chemistry, Searle Research & Development, Skokie, Illinois 60077.
出版信息
J Med Chem. 1992 Dec 25;35(26):4914-7. doi: 10.1021/jm00104a019.
PMID:1479591
Abstract
摘要
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Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Asp-carboxylate of RGDX mimetics and the platelet GP IIb-IIIa receptor.基于纤维蛋白原Arg-Gly-Asp-Phe序列的血小板聚集强效抑制剂。关于RGDX模拟物的天冬氨酸羧酸盐与血小板糖蛋白IIb-IIIa受体之间结合相互作用性质的一项提议。
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