HA - 1077可抑制血管平滑肌细胞的增殖以及c - fos信使核糖核酸的诱导。

HA-1077 suppress both proliferation of vascular smooth muscle cells and c-fos mRNA induction.

作者信息

Sase K, Yui Y, Hattori R, Shirotani M, Kawai C, Sasayama S

机构信息

Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.

出版信息

Jpn Circ J. 1992 Dec;56(12):1229-33. doi: 10.1253/jcj.56.1229.

DOI:10.1253/jcj.56.1229

PMID:1479648

Abstract

HA1077 is a newly synthesized vasodilator with unique intracellular calcium antagonistic action. In this study, its effect on the growth of vascular smooth muscle cells (VSMC) stimulated by fetal calf serum was examined. Both the proliferation and [3H]thymidine incorporation into DNA of the growth-arrested VSMC was dose-dependently inhibited by HA1077. The expression of a proto-oncogene, c-fos, which reached the maximum 30 min after addition of serum, was similarly inhibited by this agent in a dose-dependent manner. Thus, HA1077 is expected to be a useful vasodilator agent capable of suppressing the growth of VSMC which is thought to be an important underlying mechanism of atherosclerosis or restenosis after angioplasty.

摘要

HA1077是一种新合成的血管扩张剂，具有独特的细胞内钙拮抗作用。在本研究中，检测了其对胎牛血清刺激的血管平滑肌细胞（VSMC）生长的影响。HA1077剂量依赖性地抑制了生长停滞的VSMC的增殖以及[3H]胸腺嘧啶核苷掺入DNA的过程。原癌基因c-fos的表达在加入血清后30分钟达到峰值，该药物同样以剂量依赖性方式抑制了这种表达。因此，HA1077有望成为一种有用的血管扩张剂，能够抑制VSMC的生长，而VSMC的生长被认为是动脉粥样硬化或血管成形术后再狭窄的重要潜在机制。