Takeda J, Kondo M, Okamoto C, Takahashi J, Fukushima K
Department of Anesthesiology, School of Medicine, Keio University, Tokyo.
Masui. 1992 Dec;41(12):1956-60.
To evaluate the interaction of amrinone with inhalational anesthetics, cardiovascular effects of amrinone were investigated in nine mongrel dogs anesthetized with enflurane. Each dog received enflurane and amrinone in the following sequence: 1) 2% enflurane alone, 2) continuous infusion of 20 micrograms.kg-1.min-1 during enflurane, 3) 40 micrograms.kg-1.min-1 infusion during enflurane. Amrinone 40 micrograms.kg-1.min-1 during enflurane anesthesia improved the maximum left ventricular dP/dt, stroke volume and decreased effective arterial elastance (Ea) without changes in left ventricular end-diastolic pressure and heart rate. Left ventricular pressure (LVP) and systolic femoral arterial pressure were stable, but diastolic femoral arterial pressure decreased significantly from enflurane anesthesia alone. These parameters at 20 micrograms.kg-1.min-1 of amrinone infusion during enflurane showed the same tendency with 40 micrograms.kg-1.min-1 infusion but not significantly different from enflurane alone. This result suggests that amrinone may be beneficial in the patients with depression of cardiac performance during anesthesia.
为评估氨力农与吸入性麻醉药的相互作用，在9只接受安氟醚麻醉的杂种犬中研究了氨力农的心血管效应。每只犬按以下顺序接受安氟醚和氨力农：1）仅用2%安氟醚，2）在安氟醚麻醉期间持续输注20微克·千克⁻¹·分钟⁻¹，3）在安氟醚麻醉期间输注40微克·千克⁻¹·分钟⁻¹。在安氟醚麻醉期间输注40微克·千克⁻¹·分钟⁻¹的氨力农可改善最大左心室dp/dt、每搏量，并降低有效动脉弹性（Ea），而左心室舒张末期压力和心率无变化。左心室压力（LVP）和股动脉收缩压稳定，但股动脉舒张压较仅用安氟醚麻醉时显著降低。在安氟醚麻醉期间输注20微克·千克⁻¹·分钟⁻¹氨力农时的这些参数与输注40微克·千克⁻¹·分钟⁻¹时显示相同趋势，但与仅用安氟醚时无显著差异。该结果表明氨力农可能对麻醉期间心功能受抑制的患者有益。
