Hattori S, Hiramatsu M, Ushijima T, Karashima S, Furuse A, Matsuda I, Takebayashi S
Kumamoto University, College of Medical Science.
Nihon Jinzo Gakkai Shi. 1992 Jul;34(7):773-81.
We studied clinicopathologically 19 patients with abnormal urinary findings accompanying with persistent hypocomplementemia under age 15. They consisted of 6 patients with membranoproliferative glomerulonephritis (MPGN) type I, 2 with MPGN type II, 2 with focal MPGN, 8 with diffuse proliferative glomerulonephritis (DPGN), 1 with focal glomerulonephritis (FGN). 17 cases were treated with steroid. In 2 patients with MPGN type I and 1 patient with DPGN, the treatment resulted in normalization of serum C3 level and urinary abnormalities and improvement of histological findings. In 3 patients with DPGN, urinary abnormalities and hypocomplementemia have been persisted and histological findings changed to those of MPGN type I. Thus, DPGN with hypocomplementemia seems to be an early stage of MPGN type I.
我们对19例15岁以下伴有持续性低补体血症且尿检异常的患者进行了临床病理研究。其中包括6例I型膜增生性肾小球肾炎（MPGN）、2例II型MPGN、2例局灶性MPGN、8例弥漫性增生性肾小球肾炎（DPGN）、1例局灶性肾小球肾炎（FGN）。17例患者接受了类固醇治疗。在2例I型MPGN和1例DPGN患者中，治疗使血清C3水平和尿检异常恢复正常，组织学表现得到改善。在3例DPGN患者中，尿检异常和低补体血症持续存在，组织学表现转变为I型MPGN。因此，伴有低补体血症的DPGN似乎是I型MPGN的早期阶段。
