Satoh M, Ohta S, Nagao T, Hirobe M, Fukuda H, Ono H
Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Jpn J Pharmacol. 1992 Oct;60(2):121-5. doi: 10.1254/jjp.60.121.
The amphetamine-related compounds methamphetamine, phenylethylamine and nomifensine increased the K(+)-evoked release of endogenous noradrenaline from rat spinal cord slices. 4-Phenyl-1,2,3,4-tetrahydroisoquinoline (4PTIQ), which alone did not affect the K(+)-evoked release of noradrenaline, inhibited the noradrenaline-releasing effects of methamphetamine, phenylethylamine and nomifensine. 4PTIQ revealed a weak noradrenaline-uptake inhibitory effect, and the effect was weaker than those of desipramine and nomifensine. These results showed that 4PTIQ is an antagonist against the amine-releasing effects of amphetamines.
