Laber-Laird K, Smith A, Swindle M M, Colwell J
Medical University of South Carolina, Department of Comparative Medicine, Charleston 29425-2216.
Lab Anim Sci. 1992 Dec;42(6):579-81.
Isoflurane's effect on intravenous glucose tolerance and insulin secretion was studied in six Yucatan minipigs. Unanesthetized animals, with previously placed indwelling venous catheters, were tested while resting comfortably in slings. The same animals were then retested during isoflurane anesthesia. Serum glucose and insulin concentrations were measured at predetermined times in response to an intravenous bolus of dextrose. The glucose disappearance rate (k), baseline plasma insulin concentration, the area under the insulin response curve, and the insulinogenic index were significantly lower in the anesthetized animals than in controls. The results of this study indicate that anesthesia with isoflurane significantly alters the glucose/insulin response to an intravenous glucose tolerance test and, therefore, is unsuitable for studies when glucose tolerance is to be assessed.
在六只尤卡坦小型猪中研究了异氟烷对静脉葡萄糖耐量和胰岛素分泌的影响。对先前已留置静脉导管的未麻醉动物，在其舒适地躺在吊床中休息时进行测试。然后在异氟烷麻醉期间对同一批动物进行重新测试。在静脉注射葡萄糖推注后的预定时间测量血清葡萄糖和胰岛素浓度。麻醉动物的葡萄糖消失率（k）、基线血浆胰岛素浓度、胰岛素反应曲线下面积和胰岛素生成指数均显著低于对照组。本研究结果表明，异氟烷麻醉会显著改变静脉葡萄糖耐量试验中的葡萄糖/胰岛素反应，因此，在评估葡萄糖耐量时不适合用于研究。
