Willner P, Muscat R, Papp M
Department of Psychology, City of London Polytechnic, London, UK.
Neurosci Biobehav Rev. 1992 Winter;16(4):525-34. doi: 10.1016/s0149-7634(05)80194-0.
Chronic sequential administration of a variety of mild stressors causes a decrease in responsiveness to rewards in rats, which is reversed by chronic administration of antidepressant drugs. This paper reviews the validity of chronic mild stress-induced anhedonia as an animal model of depression, and the evidence that changes in hedonic responsiveness in this model are mediated by changes in the sensitivity of dopamine D2 receptors in the nucleus accumbens. The review opens with an analysis of the design features of animal models of depression, and ends with a brief account of other animal models of anhedonia.
对大鼠长期依次给予多种轻度应激源会导致其对奖励的反应性降低，而长期给予抗抑郁药物可逆转这种降低。本文综述了慢性轻度应激诱导快感缺失作为抑郁症动物模型的有效性，以及该模型中快感反应性变化是由伏隔核中多巴胺D2受体敏感性变化介导的证据。综述开篇分析了抑郁症动物模型的设计特点，结尾简要介绍了其他快感缺失动物模型。
