Babichev V N, Adamskaia E I, Peryshkova T A
Probl Endokrinol (Mosk). 1992 Sep-Oct;38(5):9-12.
Selective secretion of FSH, involving no apparent changes in LH secretion, was studied in cycling rat females in the late proestrus and early estrus stages. The preovulatory wave of LH and FSH secretion, observed in the second half of the day of proestrus was associated with elevation of the levels of nuclear estrogenic and androgenic receptors. High concentrations of both receptor types were seen during a secondary elevation of FSH secretion early in the morning in the estrus stage. Administration of phentolamine (alpha-adrenoreceptor blocker) did not influence blood levels of FSH and LH in the estrus stage early hours. Administration of a dopamine blocker haloperidol inhibited the second wave of FSH secretion, this being paralleled by a reduction of the number of estradiol nuclear receptors. The authors suggest that estrogenic and androgenic receptors of adenohypophysis and dopaminergic systems of the brain contribute to the mechanism of regulation of the second phase of FSH increased secretion observed in the early morning hours of the estrus stage, the dopamine effect on FSH release being mediated via estradiol receptors.
在发情后期和发情前期的成年雌性大鼠中，研究了促卵泡激素（FSH）的选择性分泌，而促黄体生成素（LH）的分泌未出现明显变化。在发情后期的后半段观察到的LH和FSH分泌的排卵前波，与核雌激素和雄激素受体水平的升高有关。在发情期清晨FSH分泌的二次升高期间，两种受体类型的浓度均较高。给予酚妥拉明（α-肾上腺素能受体阻滞剂）对发情期早期的FSH和LH血液水平没有影响。给予多巴胺阻滞剂氟哌啶醇可抑制FSH分泌的第二波，同时雌二醇核受体数量减少。作者认为，腺垂体的雌激素和雄激素受体以及大脑的多巴胺能系统参与了发情期清晨观察到的FSH分泌增加第二阶段的调节机制，多巴胺对FSH释放的影响是通过雌二醇受体介导的。
