Babichev V N, Peryshkova T A, Adamskaia E I
Probl Endokrinol (Mosk). 1989 Mar-Apr;35(2):59-62.
The level of the cytoplasmic and nuclear estradiol and testosterone receptors was investigated in the female rat hypophysis in various time-intervals of proestrus and estrus. The highest concentration of the nuclear and androgenic receptors was noted in the afternoon at the P stage during the preovulatory release of LH and FSH. After a short-term decrease in the number of the nuclear estradiol- and testosterone-binding sites at 9 and 11 p.m. at the P stage which was taking place in parallel with a decrease in the blood level of LH and FSH, their significant rise was noted at 1 and 3 a.m. at the E stage during the second wave of FSH release. However the concentration of the nuclear estrogenic receptors in these hours at the E stage was 3.5 times lower, and that of the androgenic receptors a 1.4-fold lower than their concentration at 7 p.m. at the P stage. It was assumed that the adenohypophyseal estrogenic and androgenic receptors were involved in the stimulation of the second FSH wave.
在动情前期和发情期的不同时间段，对雌性大鼠垂体中细胞质和细胞核内雌二醇和睾酮受体的水平进行了研究。在促黄体生成素（LH）和促卵泡生成素（FSH）排卵前释放的P期下午，观察到细胞核和雄激素受体的浓度最高。在P期晚上9点和11点，细胞核雌二醇和睾酮结合位点数量短暂减少，这与LH和FSH血液水平下降同时发生，而在E期凌晨1点和3点FSH释放的第二波期间，它们显著上升。然而，E期这些时间点细胞核雌激素受体的浓度比P期晚上7点时低3.5倍，雄激素受体的浓度低1.4倍。据推测，腺垂体雌激素和雄激素受体参与了FSH第二波的刺激过程。
