1,2,4-三唑并-1,3-噻嗪衍生物的合成、结构与生物活性
Synthesis, structure and biological activity of 1,2,4-triazolo-1,3-thiazine derivatives.
作者信息
Foks H, Rudnicka W, Głowka M, Kaliszan R, Nasal A, Damasiewicz B, Radwańska A, Petrusewicz J, Trzeciak H, Okopień B
机构信息
Department of Organic Chemistry, Medical Academy of Gdańsk, Poland.
出版信息
Pharmazie. 1992 Oct;47(10):770-3.
PMID:1480655
Abstract
A group of condensed triazole-thiazine derivatives (2a-i, 3b, 3j) was obtained in reaction of the corresponding 5-substituted 1,2,4-triazole-3-thiones (1a-j) with epichlorohydrin in alkaline medium. The structure of the compounds synthesized was confirmed by spectral and roentgenographic methods. Tuberculostatic and circulatory activities of the compounds were also studied.
摘要
在碱性介质中，相应的5-取代-1,2,4-三唑-3-硫酮（1a-j）与环氧氯丙烷反应，得到了一组稠合三唑并噻嗪衍生物（2a-i、3b、3j）。通过光谱和X射线衍射方法确定了所合成化合物的结构。还研究了这些化合物的抗结核活性和循环系统活性。
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