Inoue S, Nezuo S, Sawayama T, Hasegawa K, Tamura K, Tanaka J, Nakamura T, Kato T, Ebata J
Department of Medicine, Kawasaki Medical School.
Kokyu To Junkan. 1992 Dec;40(12):1209-13.
To examine the relation of autonomic function and severity of hypertrophic cardiomyopathy (HCM) with and without ventricular tachycardia (VT) and poor blood pressure response on Treadmill exercise, 30 patients with HCM and 10 healthy controls were selected. Autonomic function was assessed by heart rate variability (HRV) on 24hr-Holter monitoring. The power spectrum analysis was classified into LF component, HF component and ratio of LF/HF. (1) Night time HF and LF decreased, and LF/HF increased in HCM compared with healthy controls. (2) HF decreased more in HCM with VT. (3) LF/HF also decreased in HCM with poor blood pressure response on exercise. These results suggest that autonomic function may be altered in HCM, and severity of HCM proved to be able to be assessed by power spectrum analysis of HRV.
为研究肥厚型心肌病（HCM）伴或不伴室性心动过速（VT）以及平板运动时血压反应不佳情况下自主神经功能与疾病严重程度之间的关系，选取了30例肥厚型心肌病患者和10名健康对照者。通过24小时动态心电图监测的心率变异性（HRV）评估自主神经功能。功率谱分析分为低频成分、高频成分以及低频/高频比值。（1）与健康对照者相比，肥厚型心肌病患者夜间高频和低频成分降低，低频/高频比值升高。（2）伴室性心动过速的肥厚型心肌病患者高频成分降低更为明显。（3）运动时血压反应不佳的肥厚型心肌病患者低频/高频比值也降低。这些结果表明，肥厚型心肌病患者的自主神经功能可能发生改变，且肥厚型心肌病的严重程度可通过心率变异性的功率谱分析进行评估。
