Podrouzková B, Krusová D
II. interní klinika lékarské fakulty MU, Brno.
Vnitr Lek. 1992 Oct;38(10):963-7.
The authors evaluate treatment by a combination of insulin and gliquidone (Glurenorm) in 29 type 2 diabetics where long-term treatment with oral antidiabetics alone had failed. Within four months all patients were completely compensated from the metabolic aspect. HbA1c declined from 10.8 to 6.5, C peptide, on the other hand, increased from the original value of 1.2 ng/ml to 1.8 ng/ml. The authors did not observe any undesirable effects or hypoglycaemic states. Gliquidone is suitable for combined treatment because of its short-term effect; stimulation of endogenous secretion has a pulsed character and imitates an intensified regime. The prerequisite of success is a low dose of intermediary insulin to prevent inhibition of the central action of gliquidone.
作者评估了胰岛素与格列喹酮（糖适平）联合治疗29例2型糖尿病患者的效果，这些患者单独使用口服降糖药进行长期治疗均告失败。在四个月内，所有患者在代谢方面均得到了完全补偿。糖化血红蛋白（HbA1c）从10.8降至6.5，而C肽则从初始值1.2 ng/ml增至1.8 ng/ml。作者未观察到任何不良影响或低血糖状态。由于格列喹酮具有短期作用，刺激内源性分泌具有脉冲特性且模拟强化治疗方案，因此它适用于联合治疗。成功的前提是使用低剂量的中效胰岛素以防止抑制格列喹酮的中枢作用。
