[不同病因胸腔积液中的组织多肽抗原和肿瘤胰蛋白酶抑制剂]

[Tissue polypeptide antigen and tumor trypsin inhibitor in pleural effusions of various etiologies].

作者信息

Plavec G, Lazarov A, Odavić M, Dangubić V, Ninković M

出版信息

Vojnosanit Pregl. 1992 Jul-Aug;49(4):325-9.

Abstract

In 47 patients with pleural effusions of different etiology concentrations of the tissue polypeptide antigen (TPA) and tumour trypsin inhibitor (TATI) were measured. Malignant disease was found in 24 patients and benign one in 23 patients. In a group of patients with malignant pleural effusion the average concentration of TPA was 3102 U/L and of TATI 76.8 ug/L. In a group of patients with nonmalignant effusion these concentrations of TPA were 2381.8 U/L and of TATI 28.3 ug/L. Higher concentration of TPA was found in pleural effusion of malignant nature with specificity of 96% but with a small sensitivity of 12.5% and positive predictive value of 43%. TATI concentrations were also higher in malignant pleural effusion with good sensitivity and specificity (78%, 50% respectively) and positive predictive value of 66%.

摘要

对47例不同病因胸腔积液患者测定了组织多肽抗原（TPA）和肿瘤胰蛋白酶抑制剂（TATI）的浓度。其中24例为恶性疾病，23例为良性疾病。恶性胸腔积液组TPA平均浓度为3102 U/L，TATI为76.8 μg/L。非恶性积液组TPA浓度为2381.8 U/L，TATI为28.3 μg/L。恶性胸腔积液中TPA浓度较高，特异性为96%，但敏感性低，仅为12.5%，阳性预测值为43%。恶性胸腔积液中TATI浓度也较高，敏感性和特异性良好（分别为78%、50%），阳性预测值为66%。