Fischer H, Meller K
Medizinisch-Poliklinisches Institut, Universität Leipzig.
Zentralbl Gynakol. 1992;114(11):547-50.
Among 106 pregnant women with anaemia a typical state of iron deficiency could be shown at only 36.8%. 22.5% of the patients had a decreased vitamin B12 level without any characteristic symptoms of a megaloblastic anaemia. Predominantly the grade of the anaemia was small. The mean value of hemoglobin lied at 7.1 +/- 0.59 mmol/l. The severity of the anaemia didn't show any connection to the vitamin B12 level or parameters of the iron metabolism. With a combined therapy of iron, folic acid and vitamin B12 an increase of the Hb-level could be noticed at only 44.3% of the patients. The haematological findings, taken before the therapy, as well as the therapy results show that an important part of anaemias in pregnancy is caused by a complex genesis as a result of immunological reactions in pregnancy.
在106名贫血孕妇中,仅36.8%表现出典型的缺铁状态。22.5%的患者维生素B12水平降低,但无任何巨幼细胞贫血的特征性症状。贫血程度主要较轻。血红蛋白的平均值为7.1±0.59 mmol/l。贫血的严重程度与维生素B12水平或铁代谢参数无任何关联。采用铁、叶酸和维生素B12联合治疗时,仅44.3%的患者血红蛋白水平有所升高。治疗前的血液学检查结果以及治疗效果表明,孕期贫血的一个重要部分是由孕期免疫反应导致的复杂病因引起的。