Bardy A H
Vaajasalo Hospital, Kuopio, Finland.
Acta Neurol Scand. 1992 Nov;86(5):466-9. doi: 10.1111/j.1600-0404.1992.tb05125.x.
Eleven epileptic patients, candidates for surgical treatment, were examined in order to localize epileptic foci. The daily doses of antiepileptic drugs (AEDs) were reduced by fifty per cent or less, and the reduced dosages were maintained until a seizure had occurred. The reduction resulted in seizures within five days among all patients, and the number of seizures increased significantly in comparison with the five-day period before AED reduction. The seizures so provoked were typical for each patient, as confirmed by clinical observation and video-EEG telemetry. No status epilepticus or withdrawal psychosis occurred. The AED concentrations at the time of the seizures were generally within the reference values.
为了定位癫痫病灶，对11名有外科治疗指征的癫痫患者进行了检查。抗癫痫药物（AEDs）的每日剂量减少了50%或更少，并维持减少后的剂量直至癫痫发作。所有患者均在五天内出现癫痫发作，与AED减量前的五天相比，癫痫发作次数显著增加。经临床观察和视频脑电图遥测证实，如此诱发的癫痫发作对每位患者来说都是典型的。未发生癫痫持续状态或撤药后精神病。癫痫发作时的AED浓度一般在参考值范围内。
