Iluchev D, Shtereva S
Eksp Med Morfol. 1976;15(3):161-6.
The authors examined in dynamics the changes in the functional state of the adrenals on 240 rabbits, which served as models for acute metabolic deviations in the acid-base balance. The obtained results showed that the acute metabolic acidosis increased moderately the values of ACTH and 17-hydroxycorticosteroids in blood without changing their concentration on the adrenal tissue. It lowered strongly the content of catecholamines (adrenaline and noradranaline) in the adrenal medular part. The metabolic alkalosis raised the concentration of ACTH in blood plasma and increased the amount of corticosteroids in blood and adrenals. There was no well formed parallelism in normalizing acid-base and hormonal indices. As a consequence of this a stage of postaciodotic catecholamine adrenal deficit was formed as well as metabasic hypercorticism in the experimental animals.
作者动态研究了240只家兔肾上腺功能状态的变化，这些家兔作为酸碱平衡急性代谢偏差的模型。所得结果表明，急性代谢性酸中毒适度增加了血液中促肾上腺皮质激素（ACTH）和17-羟皮质类固醇的值，而肾上腺组织中它们的浓度没有变化。它显著降低了肾上腺髓质部分儿茶酚胺（肾上腺素和去甲肾上腺素）的含量。代谢性碱中毒提高了血浆中促肾上腺皮质激素的浓度，并增加了血液和肾上腺中皮质类固醇的量。酸碱指标和激素指标的正常化没有形成良好的平行关系。因此，在实验动物中形成了酸血症后儿茶酚胺肾上腺缺乏阶段以及碱血症性皮质功能亢进。
