犬代谢性酸中毒和碱中毒时骨钠和碳酸盐的变化。
Changes in bone sodium and carbonate in metabolic acidosis and alkalosis in the dog.
作者信息
Burnell J M
出版信息
J Clin Invest. 1971 Feb;50(2):327-31. doi: 10.1172/JCI106499.
Abstract
Metabolic acidosis and alkalosis were produced in adult dogs over 5- to 10-day periods. Midtibial cortical bone was analyzed for calcium, sodium, phosphorus, and carbonate. In acidosis bone CO(3)/Ca decreased 9.5% and bone Na/Ca decreased 6.3%. In alkalosis bone CO(3)/Ca increased 3.1% and bone Na/Ca increased 3.0%. Previous attempts to account for changes in net acid balance by summation of extra- and intracellular acid-base changes have uniformly resulted in about 40-60% of acid gained or lost being "unaccounted for." If it is assumed that changes in tibial cortex reflect changes in the entire skeletal system, changes in bone CO(3) (=) are sufficiently large to account for the "unaccounted for" acid change without postulating changes in cellular metabolic acid production.
摘要
在成年犬身上，经过5至10天的时间制造出代谢性酸中毒和碱中毒。对胫骨中段皮质骨进行钙、钠、磷和碳酸盐分析。在酸中毒时，骨CO(3)/Ca降低了9.5%，骨Na/Ca降低了6.3%。在碱中毒时，骨CO(3)/Ca增加了3.1%，骨Na/Ca增加了3.0%。以往通过细胞内外酸碱变化总和来解释净酸平衡变化的尝试，均一致导致约40%至60%获得或损失的酸“无法解释”。如果假设胫骨皮质的变化反映了整个骨骼系统的变化，那么骨CO(3)(=)的变化足够大，足以解释“无法解释”的酸变化，而无需假定细胞代谢酸产生的变化。
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