Cherpachenko N M, Zhdanov V S, Vikhert A M
Arkh Patol. 1992;54(9):12-7.
Endomyocardial biopsies from 20 patients with dilated cardiomyopathy (DCMP) were studied histochemically. The decrease of the mitochondrial enzyme activity and increase of the activity of lysosomal and hydrolytic enzymes were found. These alterations reflect degenerative processes in cardiomyocytes followed by activation of their degradation and utilization. This results in the decrease of the myocardium contractile volume and its contractile function damage. There was no correlation between the level of the enzyme activity in the myocardium and the degree of the contractile function activity. There was a tendency to the increase of the above changes in patients with early signs of coronary atherosclerosis.
对20例扩张型心肌病（DCMP）患者的心内膜心肌活检组织进行了组织化学研究。发现线粒体酶活性降低，溶酶体酶和水解酶活性增加。这些改变反映了心肌细胞的退行性变过程，随后激活了其降解和利用。这导致心肌收缩容积减少及其收缩功能受损。心肌酶活性水平与收缩功能活动程度之间无相关性。在有冠状动脉粥样硬化早期迹象的患者中，上述变化有增加的趋势。
