Piazza M, Abrescia N, Picciotto L, Cotugno M, Vegnente A, Iorio R, Cimmino L
Clinica delle Malattie Infettive, II Facoltà di Medicina e Chirurgia dell'Università di Napoli.
Boll Soc Ital Biol Sper. 1992 Jul;68(7):483-9.
27 healthy babies born to HBsAg, antiHBs and antiHBc negative mothers were given three doses of hepatitis B vaccine "Recombivax HB" (5 micrograms/dose/0.5 ml) at 3, 5 and 11 months of age (Piazza's protocol). AntiHBs response was highly satisfactory. Since both in terms of seroconversion rate and of mean antiHBs titre immunogenicity of other hepatitis B vaccines given at 3, 5 and 11 months of age was already demonstrated, it is possible to conclude that Piazza's protocol is valid for all hepatitis B vaccines available in Italy and will certainly facilitate the compulsory hepatitis B vaccination in infants in Italy.
27名母亲乙肝表面抗原（HBsAg）、乙肝表面抗体（antiHBs）和乙肝核心抗体（antiHBc）均为阴性的健康婴儿，按照皮亚扎方案，在3、5和11月龄时接种了3剂“重组酵母乙肝疫苗”（Recombivax HB，5微克/剂/0.5毫升）。乙肝表面抗体反应非常令人满意。鉴于3、5和11月龄接种的其他乙肝疫苗在血清转化率和平均乙肝表面抗体滴度方面的免疫原性均已得到证实，可以得出结论，皮亚扎方案对意大利现有的所有乙肝疫苗均有效，并且肯定会促进意大利婴儿乙肝疫苗的强制接种。
