Råstam L, Hannan P J, Luepker R V, Mittelmark M B, Murray D M, Slater J S
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis.
Am J Prev Med. 1992 Nov-Dec;8(6):360-6.
In 3,377 men and 3,900 women who participated in a community-based plasma cholesterol screening program, we found a significant cyclic time-trend in cholesterol levels, with maximum peak in January. The 95% confidence interval (CI) of the peak to trough distance was 5.8-13.8 mg/dL (0.15-0.36 mmol/L) in men, corresponding to 2.6%-6.3% of the average cholesterol level. Corresponding figures for women were 2.0-9.3 mg/dL (0.05-0.24 mmol/L) or 1.0%-4.6%. Applying the cutoff level for high cholesterol risk proposed by the National Cholesterol Education Program (< or = 240 mg/dL [6.21 mmol/L]) to sex-specific bimonthly distributions, we found a statistically significant variation in prevalence, attributable to seasonal trends, in men (P < .01), but not in women. In men, the age-adjusted prevalence in winter (25.4%) was double that in the summer (13.5%). Seasonal variation is an important determinant of the prevalence of hypercholesterolemia in men and should be considered in patient follow-up and screening.
在参与一项基于社区的血浆胆固醇筛查项目的3377名男性和3900名女性中，我们发现胆固醇水平存在显著的周期性时间趋势，1月份达到最高峰值。男性峰值到谷值的距离的95%置信区间（CI）为5.8 - 13.8毫克/分升（0.15 - 0.36毫摩尔/升），相当于平均胆固醇水平的2.6% - 6.3%。女性的相应数值为2.0 - 9.3毫克/分升（0.05 - 0.24毫摩尔/升）或1.0% - 4.6%。将国家胆固醇教育计划提出的高胆固醇风险临界值（≤240毫克/分升[6.21毫摩尔/升]）应用于按性别划分的双月分布情况，我们发现男性中因季节趋势导致的患病率存在统计学显著差异（P < .01），而女性中则没有。在男性中，冬季经年龄调整后的患病率（25.4%）是夏季（13.5%）的两倍。季节变化是男性高胆固醇血症患病率的一个重要决定因素，在患者随访和筛查中应予以考虑。
