Mochon M, Kaiser B A, deChadarevian J P, Polinsky M S, Baluarte H J
Department of Pediatrics (Section of Nephrology), St. Christopher's Hospital for Children, Temple University School of Medicine, Philadelphia, Pennsylvania 19134.
Pediatr Nephrol. 1992 Nov;6(6):550-2. doi: 10.1007/BF00866501.
A white girl with a history of atypical hemolytic-uremic syndrome (HUS) and persistent microangiopathic anemia, and thrombocytopenia for 2 months after the initial presentation at age 7 months, received her first cadaveric renal transplant at age 3 years. During the first 2.5 days post transplant, she developed progressive thrombocytopenia and anemia followed by tonic-clonic seizures and loss of consciousness, secondary to a diffuse cerebral infarction of the left hemisphere. Renal histology showed evidence of glomerular microthrombi and microangiopathy. A large cerebral infarct, previously described in patients during their initial presentation with HUS, presented in our patient as part of the recurrence of the disease post renal transplantation.
