一种存在于内分泌组织中的酶，可将5-3羟基类固醇氧化为δ5-3不饱和酮。 - Suppr

Suppr

超能文献

An enzyme in endocrine tissues which oxidizes 5-3 hydroxy steroids to delta 5-3 unsaturated ketones.

作者信息

SAMUELS L T, HELMREICH M L, LASATER M B, REICH H

出版信息

Science. 1951 Apr 27;113(2939):490-1. doi: 10.1126/science.113.2939.490.

DOI:10.1126/science.113.2939.490

PMID:14828376

Abstract

摘要

相似文献

An enzyme in endocrine tissues which oxidizes 5-3 hydroxy steroids to delta 5-3 unsaturated ketones.一种存在于内分泌组织中的酶，可将5-3羟基类固醇氧化为δ5-3不饱和酮。

Science. 1951 Apr 27;113(2939):490-1. doi: 10.1126/science.113.2939.490.

Oxidation mechanism of 7-hydroxy-delta 8-tetrahydrocannabinol and 8-hydroxy-delta 9-tetrahydrocannabinol to the corresponding ketones by CYP3A11.细胞色素P450 3A11介导7-羟基-δ8-四氢大麻酚和8-羟基-δ9-四氢大麻酚氧化生成相应酮类的机制

Drug Metab Dispos. 2001 Nov;29(11):1485-91.

Hydroxy-steroids. V. Oxidation of 2-hydroxymethylene-4, 4-dimethyl-3-ketones with alkaline peroxide.

J Chem Soc Perkin 1. 1966;14:1277-80. doi: 10.1039/j39660001277.

The preparation of steroidal delta ... 5(10),9(11)-3-ketones.甾体△…5(10),9(11)-3-酮的制备。

Steroids. 1966 Jul;8(1):87-107. doi: 10.1016/0039-128x(66)90121-8.

One-pot, high yield synthesis of alpha-ketols from Delta5-steroids.

Steroids. 2006 Mar;71(3):266-72. doi: 10.1016/j.steroids.2005.11.002. Epub 2005 Dec 20.

Succinic dehydrogenase activity of certain endocrine tissues of the rat.大鼠某些内分泌组织的琥珀酸脱氢酶活性

Arch Biochem. 1946 Jan;9:69-74.

On the enzymic conversion of delta 4-3-hydroxy steroids to delta 4-3-ketones.关于δ4-3-羟基类固醇向δ4-3-酮的酶促转化。

Biochim Biophys Acta. 1957 May;24(2):431. doi: 10.1016/0006-3002(57)90219-6.

Isolation and structure elucidation of new radical oxidation products of 5-hydroxy steroids.5-羟基甾体新自由基氧化产物的分离与结构解析

Steroids. 2006 Jun;71(6):504-9. doi: 10.1016/j.steroids.2006.01.008. Epub 2006 Mar 15.

Metabolism of 11-oxygenated steroids. Metabolism in vitro by preparations of liver.11-氧化甾体的代谢。肝脏制剂的体外代谢。

Biochem J. 1968 Mar;107(2):239-58. doi: 10.1042/bj1070239.

Microbial Baeyer-Villiger oxidation of 5α-steroids using Beauveria bassiana. A stereochemical requirement for the 11α-hydroxylation and the lactonization pathway.使用球孢白僵菌对5α-甾体进行微生物拜耳-维利格氧化。11α-羟基化和内酯化途径的立体化学要求。

Steroids. 2014 Apr;82:44-52. doi: 10.1016/j.steroids.2014.01.006. Epub 2014 Jan 30.

引用本文的文献

Butyric acid ameliorates PCOS-related reproductive dysfunction through gut-brain-ovary axis signaling and ovarian steroidogenic factor activation.丁酸通过肠-脑-卵巢轴信号传导和卵巢类固醇生成因子激活改善多囊卵巢综合征相关的生殖功能障碍。

Front Endocrinol (Lausanne). 2025 Jul 9;16:1604302. doi: 10.3389/fendo.2025.1604302. eCollection 2025.

History of Adrenal Research: From Ancient Anatomy to Contemporary Molecular Biology.肾上腺研究史：从古代解剖学到当代分子生物学。

Endocr Rev. 2023 Jan 12;44(1):70-116. doi: 10.1210/endrev/bnac019.

Δ5-3β-hydroxysteroid dehydrogenase/Δ5-Δ4-ketosteroid isomerase (3β-HSD), a possible enzyme of cardiac glycoside biosynthesis, in cell cultures and plants of Digitalis lanata EHRH.Δ5-3β-羟甾脱氢酶/Δ5-Δ4-酮甾体异构酶（3β-HSD），可能是洋地黄生物合成的一种酶，在毛地黄细胞培养物和植物中。

Plant Cell Rep. 1990 Mar;8(10):621-4. doi: 10.1007/BF00270068.

Regulation of 3β-hydroxysteroid dehydrogenase/Δ⁵-Δ⁴ isomerase: a review.3β-羟甾脱氢酶/Δ5-Δ4 异构酶的调节：综述。

Int J Mol Sci. 2013 Sep 2;14(9):17926-42. doi: 10.3390/ijms140917926.

HISTOCHEMISTRY OF 3-BETA-HYDROXYSTEROID DEHYDROGENASE IN MONKEY ADRENAL CORTEX.猕猴肾上腺皮质中3-β-羟基类固醇脱氢酶的组织化学

Experientia. 1963 Nov 15;19:569-70. doi: 10.1007/BF02150992.

The adrenogenital syndrome with deficiency of 3 beta-hydroxysteroid dehydrogenase.伴有3β-羟类固醇脱氢酶缺乏的肾上腺生殖器综合征

J Clin Invest. 1962 Nov;41(11):2086-92. doi: 10.1172/JCI104666.

[Histochemical studies on hydroxysteroid dehydrogenase activity of the adrenals and ovaries of rats and rabbits].[大鼠和家兔肾上腺及卵巢中羟类固醇脱氢酶活性的组织化学研究]

Arch Gynakol. 1963;197:583-600. doi: 10.1007/BF00668401.

Histochemistry of steroid -3beta-ol dehydrogenase in the human adrenal cortex.人类肾上腺皮质中甾体-3β-醇脱氢酶的组织化学

Experientia. 1962 Mar 15;18:119-20. doi: 10.1007/BF02153847.

[Sexual hormones in women; historical survey and outlook].[女性性激素；历史回顾与展望]

Klin Wochenschr. 1958 Dec 15;36(24):1145-52. doi: 10.1007/BF01481645.

Leydig cell and delta 5-3 beta-hydroxysteroid dehydrogenase activity in the testis of toad (Bufo melanostictus) following cold exposure.暴露于寒冷环境后蟾蜍（黑眶蟾蜍）睾丸中的莱迪希细胞和δ5-3β-羟基类固醇脱氢酶活性

Experientia. 1982 Jun 15;38(6):692-3. doi: 10.1007/BF01964100.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验